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DKM 2-93

CAS No. 65836-72-8

DKM 2-93( —— )

Catalog No. M20848 CAS No. 65836-72-8

DKM 2-93 is a relatively selective inhibitor of UBA5(IC50 : 430 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
25MG 27 In Stock
50MG 41 In Stock
100MG 61 In Stock
200MG 107 In Stock
500MG 213 In Stock
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Biological Information

  • Product Name
    DKM 2-93
  • Note
    Research use only, not for human use.
  • Brief Description
    DKM 2-93 is a relatively selective inhibitor of UBA5(IC50 : 430 μM).
  • Description
    DKM 2-93 is a relatively selective inhibitor of UBA5(IC50 : 430 μM).
  • In Vitro
    Ubiquitin-like modifier activating enzyme 5 (UBA5) is a novel pancreatic cancer therapeutic target. DKM 2-93 impairs pancreatic cancer cell survival through covalently modifying the catalytic cysteine of UBA5, thereby inhibiting its activity as a protein that activates the ubiquitin-like protein UFM1 to UFMylate proteins. DKM 2-93 inhibits PaCa2 and Panc1 cells survival with IC50s of 90 and 30 μM, respectively.
  • In Vivo
    DKM 2-93 daily treatment significantly impairs tumor growth of PaCa2 cells in vivo in tumor xenograft studies in immune-deficient mice without causing any weight loss or overt toxicity.
  • Synonyms
    ——
  • Pathway
    Proteasome/Ubiquitin
  • Target
    E1
  • Recptor
    UBA5
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    65836-72-8
  • Formula Weight
    243.69
  • Molecular Formula
    C11H14ClNO3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:150 mg/mL (615.54 mM)
  • SMILES
    COc1ccc(CNC(=O)CCl)cc1OC
  • Chemical Name
    2-Chloro-N-(34-dimethoxy-benzyl)-acetamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Roberts A M Miyamoto D K Huffman T R et al. Chemoproteomic Screening of Covalent Ligands Reveals UBA5 As a Novel Pancreatic Cancer Target[J]. ACS Chemical Biology 2017 12(4):899-904.
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